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Allergies, Hypersensitivities &immunology:

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Allergies, also known as allergic diseases, are a numberofconditions caused by hypersensitivity of the immune systemtosomething in the environment that usually causes little probleminmost people.These diseases include hay fever, foodallergies,atopic dermatitis, allergic asthma, andanaphylaxis.Symptoms mayinclude red eyes, an itchy rash, runnynose, shortness of breath,or swelling. Food intolerances and foodpoisoning are separateconditions

Common allergens include pollen and food. Metals andothersubstances may also cause problems. Food, insect stings,andmedications are common causes of severe reactions.Theirdevelopment is due to both genetic and environmental factors.Theunderlying mechanism involves immunoglobulin E antibodies(IgE),part of the body's immune system, binding to an allergen andthento a receptor on mast cells or basophils where it triggerstherelease of inflammatory chemicals such as histamine.Diagnosisistypically based on a person's medical history. Further testingofthe skin or blood may be useful in certain cases. Positivetests,however, may not mean there is a significant allergy tothesubstance in question

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